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Mesenchymal Stem Cells Therapy in Diabetes Type 1 – Treating Diabetes with Stem Cells – Information

Stem Cells Therapy and Treatment for Diabetics

It is estimated that about 8 per cent of all of the diabetics patients have Type 1 Diabetes. This type is not related to lifestyle or diet. The reason for Type 1 Diabetes is still unknown.  When you suffer from Type 1 diabetes, your own body cells attack beta-cells in the pancreas where the hormone called insulin is produced. Because of this, the organ cannot produce any insulin. The role of insulin is essential – it lets the glucose in our blood to get to the cells in our bodies and gives us energy – fuel. When you are a diabetic with Type 1 diabetes, the body system breaks down the carbohydrates from the food you eat and breaks it into glucose, which cannot enter your body cells, as there is no insulin. As an effect, there is more glucose in your bloodstream. It is our main source of energy.

This causes the excess amount of blood sugar, which may lead to some serious complications. Some of the most popular are obesity, fatigue, increased urination and thirst, sight problems. Without continuous treatment, the complications may be life-threatening: Strokes, Heart Attacks, Cataracts, Glaucoma, Diabetic Foot etc.

To this moment there was no cure for Diabetes 1 available. The Stem Cell Therapy for Diabetes is a new hope for the people who suffer from Type 1 Diabetes.

The idea of using Mesenchymal Stem Cells therapy to treat Diabetes Type 1 is based on great success in treating animals with this method. There are now many clinical trials going on to prove the efficacy of this method, every single study found MSC’s to be safe for use, with no severe or adverse reactions reported and effective for use, with patients showing measurable clinical benefit. (https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-017-0233-1)

The studies are still ongoing, the results are not published yet. Many of Patients decided to travel abroad for the diabetes stem cells treatment, where this method is already available. 

What are Stem Cells and how they can help in diabetes treatment?

Stem Cells are unique biological cells that have the ability to become many different types of cells and can divide to produce more of the stem cells same type – they can replicate rapidly. They are vital in the body’s healing process. The discovery of stem cells in the umbilical cord has been a huge step in the stem cells reproductive medicine, as using the stem cells from the donor may not always be compatible, and using our own cells may be connected with duplication a genetic mistake. There is a huge potential in treating diseases previously recognized as untreatable, with stem cells.  

 

Which kind of Stem Cells are applicable in Diabetes Therapy?

The special stem cells used in diabetes therapy are cells that come from the human umbilical cord, Wharton’s Jelly. These stem cells are called allogeneic mesenchymal – mesenchymal stem cells (MSCs). The umbilical cords are donated by moms after healthy births, and all are screened for bacterias and viruses due to the Stem Cells Bank Guidelines.

Mesenchymal Stem Cells from Wharton’s Jelly are ideal for diabetes Type 1 treatment as the body does not recognize them as foreign. They also do not carry any risk of genetic disorders. These wonderful cells are able to differentiate into brain cells, neurons, and rebuild the brain areas, which do not function properly causing diabetes Type 1.

 

How do stem cells treat diabetes?
Stem cells are differentiating into cell types needed by the body – they “Scan” body tissues and spot places, where infections are, or some other cells are degenerated and need fixing –  neurons, oligodendrocytes, blood cells etc. Lost (broken, impaired) neuron connections in the brain are restored by new ones, new neuron connections are built, the brain reaction speeds up. The same thing happens in other organs as the pancreas. Stem cells cause the improvement of synaptic transmission and allow you to oxygenate the organs better.
Why are mesenchymal stem cells better for diabetes Type 1 treatment than other stem cells?
  • MSCs from Wharton’s Jelly show reduced the incidence of GVHD- graft-versus-host disease
  • MSCs from the umbilical cord are more tolerant of tissue mismatches
  • Umbilical cord stem cells show a decreased risk of any transmissible viral infections
  • Preserved cord stem cells have the ability to cross the blood-brain barrier
  • Wharton’s jelly stem cells are able to differentiate into neurons and other brain cells and tissues
Please note, that this therapy is available as a medical experiment, and a qualification process depends on meeting the criteria as well as a positive opinion of a bioethical committee. 

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